<p><strong>In this episode:</strong></p><h2>00:46 Using genomics to explain geographic differences in cancer risk</h2><p>The risk of developing cancer can vary hugely depending on geographic region, but it’s not exactly clear why. To get a better idea, a team has compared the genomes of kidney cancers taken from people around the globe. They reveal a link between geographical locations and specific genetic mutations, suggesting that there are as-yet unknown environmental or chemical exposures in different locations. They hope this work will inform public health efforts to identify and reduce potential causes of cancer.</p><p><em>Research Article: </em><a href="https://go.nature.com/4dwHCZI" rel="noopener noreferrer" target="_blank"><em>Senkin et al.</em></a></p><p><em>News and Views: </em><a href="https://go.nature.com/4dj6fJb" rel="noopener noreferrer" target="_blank"><em>Genomics reveal unknown mutation-promoting agents at global sites</em></a></p><h2></h2><h2>07:46 Research Highlights</h2><p>Research reveals that the extinct ‘sabre-toothed salmon’ actually had tusks, and a common fungus that can clean up both heavy-metal and organic pollutants.</p><p><em>Research Highlight: </em><a href="https://www.nature.com/articles/d41586-024-01146-w?utm_source=naturepod&utm_medium=podcast&utm_campaign=shownotes" rel="noopener noreferrer" target="_blank"><em>This giant extinct salmon had tusks like a warthog</em></a></p><p><em>Research Highlight: </em><a href="https://www.nature.com/articles/d41586-024-01145-x?utm_source=naturepod&utm_medium=podcast&utm_campaign=shownotes" rel="noopener noreferrer" target="_blank"><em>Garden-variety fungus is an expert at environmental clean-ups</em></a></p><h2></h2><h2>09:55 How disrupting a male mouse’s microbiome affects its offspring</h2><p>Disruption of the gut microbiota has been linked to issues with multiple organs. Now a team show disruption can even affect offspring. Male mice given antibiotics targeting gut microbes showed changes to their testes and sperm, which lead to their offspring having a higher probability of severe growth issues and premature death. Although it’s unknown whether a similar effect would be seen in humans, it suggests that factors other than genetics play a role in intergenerational disease susceptibility.</p><p><em>Research article: </em><a href="https://www.nature.com/articles/s41586-024-07336-w?utm_source=naturepod&utm_medium=podcast&utm_campaign=shownotes" rel="noopener noreferrer" target="_blank"><em>Argaw-Denboba et al.</em></a></p><p><em>News and Views: </em><a href="http://www.nature.com/articles/d41586-024-01191-5?utm_source=naturepod&utm_medium=podcast&utm_campaign=shownotes" rel="noopener noreferrer" target="_blank"><em>Dad’s gut microbes matter for pregnancy health and baby’s growth</em></a></p><h2></h2><h2>17:23 Briefing Chat</h2><p>An updated atlas of the Moon that was a decade in the making, and using AI to design new gene-editing systems.</p><p><em>Nature News: </em><a href="https://www.nature.com/articles/d41586-024-01223-0?utm_source=naturepod&utm_medium=podcast&utm_campaign=shownotes" rel="noopener noreferrer" target="_blank"><em>China's Moon atlas is the most detailed ever made</em></a></p><p><em>Nature News: </em><a href="https://www.nature.com/articles/d41586-024-01243-w?utm_source=naturepod&utm_medium=podcast&utm_campaign=shownotes" rel="noopener noreferrer" target="_blank"><em>‘ChatGPT for CRISPR’ creates new gene-editing tools</em></a></p><p><a href="https://www.nature.com/briefing/signup?utm_source=podcast-organic&utm_medium=podcast&utm_campaign=briefing-signup&utm_content=shownotes" rel="noopener noreferrer" target="_blank"><strong><em>Subscribe to Nature Briefing, an unmissable daily round-up of science news, opinion and analysis free in your inbox every weekday.</em></strong></a></p><hr><p style='color:grey; font-size:0.75em;'> Hosted on Acast. See <a style='color:grey;' target='_blank' rel='noopener noreferrer' href='https://acast.com/privacy'>acast.com/privacy</a> for more information.</p>

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Dad's microbiome can affect offsprings' health — in mice

Nature Podcast